An efficient transition-metal-free route to oligo-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>α</mml:mi></mml:math>-pyridylamines via fluoroarenes
نویسندگان
چکیده
The new polynucleating tripodal proligand H 6 tren(dpa) 3 , containing thirteen nitrogen donors of four different types, was designed, synthesized, and isolated in good yield (∼60%) via a transition-metal-free triple N-arylation tren with HXdpa (X = Br or F), using K 2 CO Cs as base (H tris(2-aminoethyl)amine, 6-halogeno-N-(pyridin-2-yl)pyridin-2-amine). HFdpa prepared excellent (90–92%) by reaction 2,6-difluoropyridine 2-aminopyridine LiH/toluene/pyridine found more reactive than HBrdpa, affording higher conversion yield. Use turned out to be essential for achieving high regioselectivity eliminating overarylation almost completely.
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ژورنال
عنوان ژورنال: Comptes Rendus Chimie
سال: 2023
ISSN: ['1878-1543', '1631-0748']
DOI: https://doi.org/10.5802/crchim.223